Evolving Treatment Paradigm in the Treatment of Locally Advanced Rectal Cancer

Side Effects of Neoadjuvant Treatment in Locally Advanced Rectal Cancer

Locally recurrent rectal cancer: treatment options

primary tumor. From 20% to 50% of patients with LR have isolated the local recurrence without distant metastasis. LR may be accompained with pain, bleeding or constipation, depending on the type of the previous surgery. The management of the isolated locoregional recurrence is difficult and treatment options may be limited in patients who have already received a local radiation therapy for the ...

Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer

The aim of this study was to evaluate the efficacy of helical tomotherapy plus capecitabine as a preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). Thirty-six LARC patients receiving preoperative CRT were analyzed. Radiotherapy (RT) consisted of 45 Gy to the regional lymph nodes and simultaneous-integrated boost (SIB) 50.4 Gy to the tumor, 5 days/week f...

Immunotherapy: an evolving paradigm in the treatment of advanced cervical cancer.

PURPOSE In 2014, the US Food and Drug Administration approved the first targeted agent, bevacizumab, in the treatment of advanced stage, persistent, or recurrent cervical cancer. This oncologic milestone has catalyzed interest in the investigation of alternate therapies, including immunotherapy, in an effort to extend life and possibly cure patients with advanced stage disease. METHODS This r...

Selection Criteria for the Radical Treatment of Locally Advanced Rectal Cancer

There are over 14,000 newly diagnosed rectal cancers per year in the United Kingdom of which between 50 and 64 percent are locally advanced (T(3)/T(4)) at presentation. Pelvic exenterative surgery was first described by Brunschwig in 1948 for advanced cervical cancer, but early series reported high morbidity and mortality. This approach was later applied to advanced primary rectal carcinomas wi...